Promethazine HCl Oral Remedy administered to the Expecting female in just two weeks of shipping might inhibit platelet aggregation in the new child.
Excessively massive dosages of antihistamines, which includes promethazine hydrochloride, in pediatric individuals may possibly bring about sudden Dying (see OVERDOSAGE). Hallucinations and convulsions have transpired with therapeutic doses and overdoses of promethazine hydrochloride in pediatric patients. In pediatric sufferers that are acutely sick associated with dehydration, There is certainly an elevated susceptibility to dystonias with using promethazine HCl.
Breathing issues (respiratory despair)that can lead to Demise and opioid withdrawal can come about if You begin getting or prevent getting other medicines though taking Promethazine Hydrochloride and Codeine Phosphate Oral Solution, which includes:
Sufferers really should be encouraged to measure Promethazine HCl Oral Solution with an correct measuring device. A home teaspoon isn't an correct measuring gadget and could lead to overdosage, particularly when a 50 percent a teaspoon is measured. A pharmacist can recommend an proper measuring unit and can provide instructions for measuring the right dose. Promethazine HCl Oral Remedy may induce marked drowsiness or impair the mental and/or Actual physical abilities demanded for the general performance of potentially harmful tasks, like driving a car or functioning machinery. Ambulatory sufferers should be advised to prevent partaking in these types of things to do right up until it is understood that they don't become drowsy or dizzy from promethazine therapy.
Codeine has minimal plasma protein binding with about seven to 25% of codeine sure to plasma proteins. Codeine passes the blood brain barrier along with the placental barrier. Modest quantities of codeine and its metabolite, morphine, are transferred to human breast milk.
Antihistamines are contraindicated to be used inside the remedy of lower respiratory tract indicators such as asthma.
Promethazine HCl and Codeine Phosphate Oral Option exposes individuals and other customers for the hazards of opioid addiction, abuse, and misuse, which may result in overdose and Demise. Reserve Promethazine HCl and Codeine Phosphate Oral Answer for use in Grownup sufferers for whom the main advantages of cough suppression are envisioned to outweigh the hazards, As well as in whom an suitable evaluation of your etiology from the cough has long been designed.
Serious hypotension commonly responds towards the check here administration of norepinephrine or phenylephrine. EPINEPHRINE Really should not be Applied, since its use inside of a affected individual with partial adrenergic blockade might further more decrease the blood pressure.
Promethazine HCl Oral Solution may well decreased seizure threshold. It should be employed with warning in folks with seizure disorders or in persons who're using concomitant drugs, such as narcotics or neighborhood anesthetics, which can also impact seizure threshold.
A heightened possibility of specific malformations with codeine publicity like respiratory malformations, spina bifida and congenital heart defects ended up documented in a few experiments.
Despite the fact that antihistamines are already identified to make fetal mortality in rodents, the pharmacological consequences of histamine in the rodent tend not to parallel All those in male. There isn't any enough and nicely-controlled research of Promethazine HCl Oral Remedy in pregnant Females.
It is soluble in water and freely soluble in alcohol. The molecular pounds is 320.88. Its molecular formulation is C17H20N2S•HCl, and it's got the subsequent chemical construction.
Postmarketing cases of respiratory melancholy, including fatalities are noted with utilization of promethazine in pediatric individuals.
Your healthcare supplier may well do blood exams to look for adrenal gland problems. Contact your healthcare provider at once In case you have any of those signs and symptoms: